Sports and medications: 10 drugs that could harm your athletic performance
Published 31 May 2025 • By Candice Salomé
Are you a recreational athlete or competitive sportsperson? Did you know that some commonly prescribed medications can impair your performance, or even lead to disqualification? Pain relievers, asthma medications, antidepressants… Even legally prescribed substances can impact your physical abilities or be banned under anti-doping rules.
This article will help you better understand which medications to watch out for so you can train and compete safely, without compromising your health or your sporting goals.

Why are some medications banned in sports?
What is doping, and how is it regulated?
Doping refers to the use of substances or methods that artificially enhance physical or mental performance. It is tightly regulated by the World Anti-Doping Agency (WADA), which updates its list of banned substances and methods annually.
What is WADA’s role?
WADA works to promote fairness and protect athletes’ health. It publishes a list of prohibited substances and methods that applies to international competitions, and often to national events as well, depending on the sport's governing body. The list separates substances banned only during competition from those banned at all times.
What’s the difference between intentional and unintentional doping?
Sometimes athletes test positive without trying to cheat. This is known as unintentional doping, and it can happen when a prescribed or over-the-counter medication is taken without checking its ingredients. This highlights the importance of being aware of potentially risky substances.
Common medications that can impact athletic performance
Anti-inflammatories: Helpful but with risks
Non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or diclofenac are often used to ease muscle pain. While not banned, overusing them can mask injuries, delay healing, and lead to gastrointestinal or cardiovascular side effects.
Cold and cough medications: A risk for unintentional doping
Some nasal decongestants containing pseudoephedrine (like Sudafed®) are banned in high doses during competition. These stimulants can increase alertness and endurance, making them a concern in anti-doping tests.
Antidepressants, anti-anxiety meds, and sleep aids: How do they affect endurance?
Psychotropic medications such as benzodiazepines (e.g., Diazepam, Xanax®) or certain antidepressants may impair coordination, focus, and reaction time. Even if not banned, they can still reduce athletic performance.
Corticosteroids: Permitted, but with strict rules
Corticosteroids are allowed when administered locally (e.g., skin, nasal sprays), but banned if taken orally or via injection unless a Therapeutic Use Exemption (TUE) is obtained. These drugs have anti-inflammatory and mood-boosting effects, but must be used under tight medical supervision.
Asthma medications: What’s allowed?
Drugs like salbutamol (e.g., Ventolin®) are allowed within specific dosage limits. Exceeding these limits can lead to a positive test. It's crucial to follow prescribed dosages carefully.
Key categories of substances banned by WADA
Stimulants
Includes amphetamines, methylphenidate, and pseudoephedrine. They boost alertness, focus, and delay fatigue.
Anabolic steroids
Used to build muscle mass and strength, anabolic steroids are strictly prohibited and considered a major class of performance-enhancing drugs.
Growth hormones and EPO
Human growth hormone and erythropoietin (EPO) promote muscle development and stamina by increasing red blood cell count.
Beta-blockers
Banned in sports requiring calm and steady hands, like shooting, due to their ability to slow heart rate and reduce anxiety.
Narcotics and cannabinoids
Substances like morphine, fentanyl, and cannabis are prohibited in competition because they affect concentration, coordination, and competitive fairness.
Diuretics
Often used to mask other banned substances, making them a serious doping violation.
Can prescription medications trigger a positive doping test?
Prescription drugs that can result in a positive test
Medications like Ritalin® (methylphenidate, used for ADHD) or cough syrups with codeine can trigger a positive test, even if taken legally. While not intentional doping, the consequences can still be significant.
What is a Therapeutic Use Exemption (TUE)?
A TUE allows an athlete to use a medically necessary treatment that appears on WADA’s banned list. The application must be submitted to the national anti-doping authority with supporting medical documentation.
Best practices for athletes on medication
- Always consult a sports medicine doctor before starting any treatment, even for seemingly minor ailments.
- Check the active ingredients against the WADA prohibited list to avoid unexpected violations.
- Track your dosages and keep medical records up to date in case of a doping control.
How can athletes check if a medication is allowed?
Online tools and databases
Resources like Global DRO (used in the US and UK) help determine whether a medication is banned in or out of competition.
The role of healthcare providers
Doctors and pharmacists must be informed of an athlete’s sport activities so they can tailor prescriptions and avoid risky substances.
What are the consequences of a positive test?
Possible sanctions
A positive doping test, even if unintentional, can lead to temporary or lifetime suspension, disqualification of results, and financial penalties. Amateur athletes are not exempt from these rules.
Appeals and challenges
Athletes can request a second analysis or contest the findings. If a TUE has been submitted, it may be considered during the review process.
Conclusion
Athletes should never take medication lightly. Some drugs can impact performance or carry serious penalties if used improperly. It's essential to stay informed, consult a healthcare provider, and check whether a treatment is allowed before any competition. When it comes to performance and safety, prevention is the best strategy.
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