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What is biologic therapy? A focused look at inflammatory diseases

Published 24 Oct 2019 • By Camille Dauvergne

What is Biologic therapy? How can it be used to treat inflammatory diseases? At what point and under what conditions can a patient have access to biologic therapy? We explain it all!

What is biologic therapy? A focused look at inflammatory diseases

Biologic therapy (also known as biotherapy or biological therapy) is built upon medications and therapeutic strategies obtained from living organisms and biological processes. At the most basic level they consist of molecules collected from living things such as yeasts, microbes, genes, cells, tissue, etc. or from substances harvested from organisms such as hormones, antibodies or interleukins.

Different kinds of biologic therapies

The term “biologic therapy” covers several different types of therapy.

  • Cellular therapy: Stem cell or differentiated cell transplants
  • Tissue therapy: Tissue transplants
  • Gene therapy: Gene transplants and other procedures performed on a genetic level
  • Biomedicine: Medications that imitate molecules found naturally in the human body and are synthesised by living organisms (growth factors, interleukins, recombinant proteins)

Biologic therapy and inflammatory diseases

Inflammatory diseases appear in various forms; they can occur in the joints (rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis), in the skin (psoriasis) or even in the digestive system (Crohn’s disease, ulcerative colitis).

How does it work?

All of these illnesses result from immune system dysfunction that may manifest as fever, liver disorders, cardiovascular complications, joint damage or intestinal perforations. At the root of these dysfunctions, we find cytokines (an immunity substance that regulates cell multiplication) and T and B lymphocytes (responsible for immunity). 

The biologic therapies used to treat these illnesses focus on pro-inflammatory cytokines and/or T and B lymphocytes. Their end-goal is to keep these faulty substances from provoking inflammations by blocking inflammation mechanisms.

When can a patient start on biologic therapy?

Starting a biologic therapy shouldn’t be taken lightly. The best time depends on the disease, its progression and the patient’s physical state. It’s an important decision that should be thought over carefully and supervised by a physician. Biotherapy prescriptions are limited due to high costs and risks of infection.

Inflammatory joint diseases

Biologic therapy is rarely prescribed just after diagnosis. In the case of rheumatoid arthritis, patients are generally given anti-inflammatory medications: analgesics followed by methotrexate, an antimetabolite, before starting on biologic therapy.

Inflammatory skin diseases

In the case of psoriasis, the choice of biologic therapy depends on the severity of the case and its impact on the patient's quality of life. Generally, a patient is put on a topical treatment (cream, mousse, gel) and if that doesn’t work, immunosuppressant drugs. A biologic therapy is only prescribed as a last resort and generally consists of anti-TNF agents, administered in drip form or subcutaneously (TNF is a protein that sets off the inflammatory process). A patient may also be injected with an interleukin (pro-inflammatory proteins) inhibitor.

>> Ask your questions about biotherapy for psoriasis on the forum

Biologic therapy is sometimes prescribed as a second-line treatment (i.e. in case of failure of the first-line treatment) for certain specific forms of psoriasis such as psoriatic arthritis.

Inflammatory digestive diseases

Biotherapy treatment aims to limit surgical operations and the use of corticosteroids. Sometimes an anti-TNF agent may be prescribed at the beginning of treatment for patients suffering from Crohn’s disease or ulcerative colitis.

How effective is biotherapy?

The efficacy of biologic therapies has been demonstrated in numerous conditions, and notably in inflammatory diseases. It usually takes about 12 weeks before their efficacy can be judged, but in some cases, patients report an improvement in symptoms in only 15 days. Still, biologic therapies should only be taken under medical supervision: the physician may prescribe additional tests to verify treatment effectiveness and the patient’s response.

What are the main side effects?

Biologic therapies may provoke side effects which usually cease as soon as the treatment is stopped. Side effects may be reduced or even avoided by paying special attention to hygiene measures, getting recommended vaccinations, etc.  

Immediate risks

When taking biologic therapy, a patient may experience a violent allergic reaction, called anaphylaxis. Other reactions may also appear during injection as the patient’s body may develop antibodies against the molecule. As is the case with any injection, soreness may develop at the injection site.

Infection risks

Biologic therapy slows down the immune system and may therefore cause immunodepression, meaning the body is no longer able to protect itself from bacterial and viral infections. The patient may contract sometimes severe opportunistic infections. You should contact your physician immediately if you experience any infection symptoms.

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A history of resistant infections, being over the age of 65, the presence of other chronic conditions or respiratory disease, and taking corticosteroids are all risk factors that increase the chances of infection.

What other difficulties might a patient run into?

Some biologic therapies need to be injected at home, which means the patient must learn to self-inject.

Warning: This article is a general overview and is not meant to be used as medical advice. Each patient is different and may encounter complications or variables in treatment not mentioned in the above text. Talk to your physician before starting any treatment.

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Take care!


This article was written by Louise-B with the assistance of Camille Dauvergne, a 4th-year Pharmacy student.

avatar Camille Dauvergne

Author: Camille Dauvergne, Junior Community Manager France

Camille Dauvergne is currently a Junior Community Manager at Carenity. She assists the France Community Manager in animating the platform, easing member navigation of the site and encouraging them to interact.... >> Learn more

Who reviewed it: Alizé Vives, Pharmacist, Data Scientist

Alizé holds a PharmD and a master's degree in strategy and international business from ESSEC Business School in France. She has several years of experience working with patients and members, conducting surveys for... >> Learn more

4 comments


Fullerdonna2
on 04/11/2019

I would like to say, thank you for the the article really informative.  Also it’s put my mind at rest about going on biological medication 


dadofalad78
on 15/11/2019

Thank you for this article. My son has been diagnosed with psoriatic arthritis and his doctor discussed the possibility of biologics if regular treatments don't work. Found this article on google and decided to join.


richard0804 • Ambassador
on 15/01/2020

@dadofalad78 

I have been taking various Biologic's for 6 years, I am on my third and LAST Biologic, due to the costs involved some hundreds of pounds per injection. I currently take a drug called COSENTYX. I have been very lucky in that I have not suffered any side effects taking this injection. The benefits have been extremely encouraging, my pain level has dropped from 10 to 4 on a scale of 1/10.

 COSENTYX has made a terrific difference to my quality of life. I would therefore recommend that your son takes every opportunity to receive Biologic treatment.

Good Luck My Friend

Regards Richard


RoMatt
on 19/03/2020

Thank you for this article.

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