Allopurinol (allopurinol): Reviews and patient testimonials

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Medication indications

Allopurinol 100mg Tablets

Allopurinol is indicated for reducing urate/uric acid formation in conditions where urate/uric acid deposition has already occurred (e.g. gouty arthritis, skin tophi, nephrolithiasis) or is a predictable clinical risk (e.g. treatment of malignancy potentially leading to acute uric acid nephropathy). The main clinical conditions where urate/uric acid deposition may occur are: idiopathic gout; uric acid lithiasis; acute uric acid nephropathy; neoplastic disease and myeloproliferative disease with high cell turnover rates, in which high urate levels occur either spontaneously, or after cytotoxic therapy; certain enzyme disorders which lead to overproduction of urate, for example: hypoxanthine-guanine phosphoribosyltransferase, including Lesch-Nyhan syndrome; glucose-6-phosphatase including glycogen storage disease; phosphoribosylpyrophosphate synthetase, phosphoribosylpyrophosphate amidotransferase; adenine phosphoribosyltransferase.

Allopurinol is indicated for the management of 2,8-dihydroxyadenine (2,8-DHA) renal stones related to deficient activity of adenine phosphoribosyltransferase.

Allopurinol is indicated for the management of recurrent mixed calcium oxalate renal stones in the presence of hyperuricosuria, when fluid, dietary and similar measures have failed.

Allopurinol 300mg Tablets

Allopurinol is indicated for reducing urate/uric acid formation in conditions where urate/uric acid deposition has already occurred (e.g. gouty arthritis, skin tophi, nephrolithiasis) or is a predictable clinical risk (e.g. treatment of malignancy potentially leading to acute uric acid nephropathy). The main clinical conditions where urate/uric acid deposition may occur are: idiopathic gout; uric acid lithiasis; acute uric acid nephropathy; neoplastic disease and myeloproliferative disease with high cell turnover rates, in which high urate levels occur either spontaneously, or after cytotoxic therapy; certain enzyme disorders which lead to overproduction of urate, for example: hypoxanthine-guanine phosphoribosyltransferase, including Lesch-Nyhan syndrome; glucose-6-phosphatase including glycogen storage disease; phosphoribosylpyrophosphate synthetase, phosphoribosylpyrophosphate amidotransferase; adenine phosphoribosyltransferase. Allopurinol is indicated for management of 2,8-dihydroxyadenine (2,8-DHA) renal stones related to deficient activity of adenine phosphoribosyltransferase.

Allopurinol is indicated for the management of recurrent mixed calcium oxalate renal stones in the presence of hyperuricosuria, when fluid, dietary and similar measures have failed.

Allopurinol Tablets BP 100mg

Allopurinol is indicated for reducing urate/uric acid formation in conditions where urate/uric acid deposition has already occurred (e.g. gouty arthritis, skin tophi, nephrolithiasis) or is a predictable clinical risk (e.g. treatment of malignancy potentially leading to acute uric acid nephropathy). The main clinical conditions where urate/uric acid deposition may occur are: idiopathic gout; uric acid lithiasis; acute uric acid nephropathy; neoplastic disease and myeloproliferative disease with high cell turnover rates, in which high urate levels occur either spontaneously, or after cytotoxic therapy; certain enzyme disorders which lead to overproduction of urate, for example: hypoxanthine-guanine phosphoribosyltransferase, including Lesch-Nyhan syndrome; glucose-6-phosphatase including glycogen storage disease; phosphoribosylpyrophosphate synthetase, phosphoribosylpyrophosphate amidotransferase; adenine phosphoribosyltransferase. Allopurinol is indicated for management of 2,8-dihydroxyadenine (2,8-DHA) renal stones related to deficient activity of adenine phosphoribosyltransferase.

Allopurinol is indicated for the management of recurrent mixed calcium oxalate renal stones in the presence of hyperuricosuria, when fluid, dietary and similar measures have failed.

Allopurinol Tablets BP 300mg

Allopurinol and its major metabolite, oxipurinol, act by inhibiting the enzyme xanthine oxidase, which catalyses the end stage of the metabolism of purines to uric acid. Allopurinol and its metabolites are excreted by the kidney but the renal handling is such that allopurinol has a plasma half-life of about 1 hour whereas that of oxipurinol exceeds 18 hours. Thus therapeutic effect may be achieved by once-a-day dosage.

1) Prophylactic management of gout and other conditions of excess body urate: Allopurinol is used to reduce excessive urate levels (serum is theoretically saturated with urate at a concentration between 0.38-0.42mmol/l). The higher levels seen in practice may be accounted for by: a) the formation of saturated solutions; b) protein binding of urate. Excess body urate may be indicated by hyperuricaemia and/or hyperuricosuria. It may lead to disposition of urate in the tissues or it may be present with no obvious signs or symptoms.

The main clinical manifestations of urate disposition are gouty arthritis, skin tophi and/or renal involvement: Excess body urate is frequently of idiopathic origin but may also be found in association with the following other conditions: neoplastic disease and its treatment; certain enzyme disorders which lead to overproduction of urate and involving: hypoxanthine guanine phosphoribosyl transferase, such as Lesch-Nyhan syndrome, glucose-6-phosphatase, as in von Gierke's disease or fosforibosylpyrofosfaatsynthetase; renal failure; renal calculus formation; diuretic therapy and psoriasis.

2) Calcium renal lithiasis: Allopurinol is of benefit in the prophylaxis and treatment of calcium renal lithiasis in patients with raised serum or urinary uric acid.


Route of administration: Oral
Molecule: allopurinol

Patients' opinions on Allopurinol

In brief

General satisfaction level: 6.33/10 Learn more

Treatment's effectiveness: 7.33/10 Learn more

Ease of use: 9.33/10 Learn more

Adherence to prescription: 9.00/10 Learn more

Detected side effects: 3.00/10 Learn more

Improvement in the quality of life: 7.67/10 Learn more

1 = Not at all satisfied
10 = Extremely satisfied

1 = Not at all satisfied
10 = Extremely satisfied

1 = Not at all satisfied
10 = Extremely satisfied

1 = Never
10 = Always

1 = Not at all important
10 = Extremely important

1 = Not at all satisfied
10 = Extremely satisfied

Tips and advice of the community


avatar
Sunshine5
on 16/01/2021

I have been taking Allupurinol for a few years now.  I had no side effects recently in the past 12 months and no gout attacks. 

It may be that I have avoided consuming very little amount of red meat,  and other food that could trigger it.

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avatar
Sunshine5
on 03/04/2020

I have been on Allupurinol since September 2018 to treat gout. Symptoms have become more frequent. Despite seeing a Rheumatologist and doubling dose from 100mg daily to 200, I still get very painful flare ups for no reason.

Uric acid levels often come back normal, as by the time I give blood, my symptoms ease off.

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avatar
Sunshine5
on 06/11/2019

I was diagnosed with gout in 2010. After having red meat in a broth for dinner, my index finger became stiff in 30 minutes and swollen that I could not bend the finger. 

Gout is excruciatingly painful and you are in complete agony. It often affects men more than women. The big toe is commonly affected but luckily it was not in my case. 

It comes and goes every few months and takes in my experience,  2 to 3 days until the symptoms go away.  It affects any of my fingers or thumb on either right or left hand.

Treatment includes 2 X 200mg Ibuprofen 3 to 4 times daily every 6 hours or Paracetamol 1,000mg 4 times daily every 6 hours. 

The pain will not go away instantly so it helps to buy an ice pack wrapped in the given cloth from the chemist (Boots in the UK or any other independent pharmacy).

The ice pack does not heal the pain but the cold press tricks your pain receptors in your nerves so that you feel the cold ice pack and not the pain.

My last topi was 7 times in the last 10 days of June 2019.

I was alarmed as I avoided dietary triggers such as red meat, acidic fruits and pickles that had caused gout previously. I saw a private Rheumatologist who arranged for X-rays of my hand and blood tests. Remarkably I was told no abnormalities were detected in my blood tests for uric acid.

I now have tried to eat red meat that is thoroughly cooked in moderation and have been fine.

I do not drink alcohol for religious reasons but that also increases your risk of gout if you drink too much and are overweight or obese.

I'm 5'5 tall  which is short for a male. I have visceral fat on my abs and weigh 78.5Kg. Although I'm overweight I've been more active at the gym having lost 3Kg from 81.5 start of September 2019  to 78.5Kg to present.

I suffer from epilepsy since birth so I have to be careful when exercising as I initially had quite a few seizures in September as my body was adjusting to a more vigorous exercise regime. I have identified my baseline exertion levels so I know when not to over do it in the gym and slow my physical activity if I feel a seizure coming.

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Conditions related to this medication

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Psoriasis

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