«
»

Top

New colon cancer drugs may arise from protein discovery

Published 5 Apr 2018

New colon cancer drugs may arise from protein discovery

Better treatments for colon cancer may be in sight, thanks to a new study, which reveals new ways in which a single protein could stop the disease in its tracks.

Researchers found that a protein known as APC can "put the brakes" on a number of pathways that drive the development of colon cancer.

This discovery could open the door to new drugs for the condition.

Study co-author Dr. Yashi Ahmed — who works in the Norris Cotton Cancer Center at Dartmouth College's Geisel School of Medicine in Hanover, NH — and colleagues recently reported their results in the journal Developmental Cell.

Scientists have already pinpointed APC — which is a protein endowed by the APC gene — as a possible target for the prevention of colorectal cancer; the protein regulates the growth and division of cells, stopping them from spiraling out of control and forming tumors.

On the other hand, the deactivation of APC can spur the development of colorectal cancer.

Role of APC 'broader and multifaceted'

Dr. Ahmed and colleagues explain that when it comes to the cancer-protecting role of APC, it was believed that the protein targets and destroys a single "activator" — specifically, a protein called beta-catenin — to prevent colon cancer.

By studying the APC-deficient cells of fruit flies — which harbor around 75 percent of the genes that cause human disease — the researchers uncovered other mechanisms by which APC can halt colon cancer.

"Unexpectedly," the authors say, "we find that blocking Wnt receptor activity in APC-deficient cells inhibits Wnt signaling independently of Wnt ligand. We also show that inducible loss of APC is rapidly followed by Wnt receptor activation and increased beta-catenin levels."

Dr. Ahmed says that these findings challenge the currently accepted view of how APC prevents colon cancer, "revealing that APC's role is much broader and multifaceted."

What is more, the researchers believe that their discovery could lead to new treatments for one of the most commonly diagnosed cancers.

"Because this new role of APC involves proteins on the cell surface," explains Dr. Ahmed, "targeting colorectal cancers may become easier. For example, therapeutic antibodies, which normally cannot work inside the cell, can now be used to treat colorectal cancers that have APC mutations."

Study co-author Dr. Ethan Lee, of the Department of Cell and Developmental Biology at Vanderbilt University in Nashville, TN, adds that their study may also help researchers to understand why APC mutations appear to be a key player in specific cancers.

"Certain tissues may have a backup mechanism to put the brakes on the pathway when APC is mutated," Dr. Lee speculates.

The researchers conclude that further studies are needed to uncover the deeper details of how APC can stop colon cancer.

MedicalNewsToday

Comments

You will also like

World Cancer Day: Facts and Insights!

Bladder cancer
Brain tumour
Breast cancer
Cancer
Cervical cancer
Endocrine cancer
Endometrial cancer
Gallbladder cancer
Gastrointestinal stromal tumour
Larynx cancer
Liver cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Testicular cancer
Thyroid cancer
xyz_Colon cancer

World Cancer Day: Facts and Insights!

Read the article
Telling patients to 'fight' cancer puts them under pressure

Bladder cancer
Brain tumour
Breast cancer
Cancer
Cervical cancer
Endocrine cancer
Endometrial cancer
Gallbladder cancer
Gastrointestinal stromal tumour
Larynx cancer
Liver cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Testicular cancer
Thyroid cancer
xyz_Colon cancer

Telling patients to 'fight' cancer puts them under pressure

Read the article
Cancer death rate to be cut by 22,000 using artificial intelligence – PM

Cancer

Cancer death rate to be cut by 22,000 using artificial intelligence – PM

Read the article
Lung cancer destroyed with tea leaf nanoparticles

Bladder cancer
Brain tumour
Breast cancer
Cancer
Cancer of the pleura
Cancer of the vulva
Cervical cancer
Endocrine cancer
Endometrial cancer
Esophageal cancer
Gallbladder cancer
Gastric cancer
Gastrointestinal stromal tumour
Larynx cancer
Leiomyosarcoma
Liver cancer
Neuroendocrine liver cancer
Neuroendocrine tumour
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Testicular cancer
Thymus cancer
Thyroid cancer
xyz_Colon cancer

Lung cancer destroyed with tea leaf nanoparticles

Read the article

Most commented discussions

Fact sheets