Have you heard of these new COPD treatments?

Hello everyone,

How are you doing today? 😊

I think it's important for us to stay informed about the latest advancements in COPD research and treatments. Knowledge is power when it comes to managing this disease effectively. So, let's dive into some exciting new developments:

1. Endobronchial Valve Implantation: Approved by the FDA in 2018, this treatment involves implanting small valves in the airways to redirect airflow away from damaged lung areas. It improves lung function, helps with symptoms, and allows for deeper breaths, particularly benefiting patients with emphysema.
2. Discovery of Respiratory Airway Secretory Cells (RASCs):Scientists at the University of Pennsylvania discovered a new type of cell called RASCs in human lungs. These cells have potential implications for COPD treatment as they produce proteins necessary for airway mucus and resemble stem cells for lung alveoli, offering hope for restoring normal lung function.
3. Transplanting patients' own lung cells: Researchers have explored using P63+ lung progenitor cells to regenerate damaged lung tissue in COPD patients. This involves collecting and multiplying these cells in a laboratory before transplanting them back into the patients' lungs. Initial trials showed improvements in lung function and symptom relief, paving the way for larger-scale clinical trials.
4. Hyaluronan Inhalation:

• A research team led by Drs. Stavros Garantziotis and Raffaele Incalzi investigated the use of hyaluronan, a naturally occurring long-chain sugar secreted by various tissues, including the lungs, for COPD treatment.
• In animal studies, inhaled hyaluronan has shown promise in reversing certain types of COPD.
• A study published in Respiratory Research in February 2021 examined the benefits of inhaled hyaluronan for hospitalized COPD patients requiring breathing support.
• Patients who received inhaled hyaluronan twice daily experienced shortened ventilator support duration, improved lung function, and reduced inflammation levels in their blood.
• Lab studies suggest that hyaluronan may help move thick mucus in the lungs, potentially helping COPD patients in mucus clearance.
• Exposure to pollution can degrade lung hyaluronan into smaller fragments, leading to lung irritation and inflammation. Reintroducing full-length hyaluronan may restore balance and alleviate COPD symptoms.
• Inhaled hyaluronan is considered safe, easy to administer, and acts locally in the bronchial tree without interfering with systemic drugs.
• Larger studies are planned to further evaluate hyaluronan's efficacy, dosing, and conditions for COPD and other lung diseases.
  
  

Have you heard about any of these treatments? What do you think about them? Let us know in the comments below!

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Take care now,

Somya from the Carenity team🌼

SOURCES:
- Promising cure for COPD: is a breakthrough treatment within reach?
- Experimental treatment helps patients hospitalized with COPD