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  • MS drug hope for secondary-progressive stage
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Research and useful tips - Multiple Sclerosis

MS drug hope for secondary-progressive stage

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avatar Margarita_k

Margarita_k

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23/03/2018 at 11:54

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avatar Margarita_k

Margarita_k

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Last activity on 07/10/2020 at 11:39

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1,195 comments posted | 88 in the Research and useful tips - Multiple Sclerosis group

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A study of a new drug to treat advanced cases of multiple sclerosis suggests it may be possible to delay progression of the disease in the short term, although the effects were small.

In a trial of 1,327 people, in The Lancet, 26% saw their disability worsen after three months taking siponimod compared with 32% taking a dummy drug.

'Modest effect'

Patients in this trial, which was funded by drug company Novartis, had had MS for an average of 17 years - four years with secondary MS, the advanced stage.

Most needed assistance with walking before the trial began.

When standard measures of disability were used to track their progress, there was a 21% lower risk of walking or arm movements getting worse for those given the drug, compared with those taking the placebo.

But the international research team found the drug had no effect on maintaining patients' walking speed and it had some side-effects, although it was still thought to be safe.

Lead author Prof Ludwig Kappos, from the University of Basel, said: "Although the results are not as good as we wanted to see, it is a very large study, which is robust. It means siponimod is one option to delay the disease in the advanced stage."

Dr Susan Kohlhaas, director of research at the MS Society, said: "These results bring us closer to the first ever treatment for people with secondary-progressive MS - so it's big news. This trial showed that siponimod had a modest but significant effect in slowing disability progression, which is incredibly encouraging."

'Disappointing'

But Dr Luanne Metz, from the University of Calgary, in Canada, said a second trial was needed to confirm the benefits of the drug and its impact beyond three to six months.

She said: "Although siponimod seems to reduce the time to confirmed disability in secondary-progressive MS, the treatment effect was small. In our opinion... the absence of a significant difference for the key secondary clinical outcome are disappointing results and do not suggest that siponimod is an effective treatment for secondary-progressive MS."

She added: "Trials of other novel treatments that target non-inflammatory mechanisms are still needed."

Before the drug becomes available on the NHS, it would need to be approved by the European Medicines Agency and then recommended as cost-effective by bodies in the UK.


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avatar judiea

judiea

26/03/2018 at 15:31

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avatar judiea

judiea

Last activity on 02/11/2022 at 18:44

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3 comments posted | 1 in the Research and useful tips - Multiple Sclerosis group


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I am very interested in the drug to help with m s secondary progressive as my husband has this type also to see if there is a way that would help control the symptoms and help with the stiff ness in the hands 

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Judith Allen


MS drug hope for secondary-progressive stage https://www.carenity.co.uk/forum/other-discussions/my-library-multiple-sclerosis/ms-drug-hope-for-secondaryprogressive-stage-2240 2018-03-26 15:31:02
avatar exit

Unregistered member

02/04/2018 at 12:52

I have SPMS and it has completely turned my life upside down.  Keep having lots of falls, am covered in bruises...I absolutely hate it 😕 Am waiting for something, anything, to help me deal with it all...:-(  


MS drug hope for secondary-progressive stage https://www.carenity.co.uk/forum/other-discussions/my-library-multiple-sclerosis/ms-drug-hope-for-secondaryprogressive-stage-2240 2018-04-02 12:52:41

avatar Walshya

Walshya

02/04/2018 at 15:18

avatar Walshya

Walshya

Last activity on 10/03/2021 at 00:40

Joined in 2017


2 comments posted | 1 in the Research and useful tips - Multiple Sclerosis group


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I have SPMS and there seems to be nothing out there for us. I’ve had SPMS for 20 odd years. I dream of having a day off from symptoms. I hope one day soon they find something so just for one day I feel like any other fifty one year old!!!

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Andrea.


MS drug hope for secondary-progressive stage https://www.carenity.co.uk/forum/other-discussions/my-library-multiple-sclerosis/ms-drug-hope-for-secondaryprogressive-stage-2240 2018-04-02 15:18:11

avatar Linz1978

Linz1978

02/04/2018 at 15:25

avatar Linz1978

Linz1978

Last activity on 06/02/2019 at 22:45

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4 comments posted | 3 in the Research and useful tips - Multiple Sclerosis group


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I have spms and I have been taking CBD oil for the last month, I have found I am sleeping ALL night had no painkillers what so ever!! And my walking and speech have improved. So I think I will continue with it, 100% legal no side effects so it’s a win win situation 😊


MS drug hope for secondary-progressive stage https://www.carenity.co.uk/forum/other-discussions/my-library-multiple-sclerosis/ms-drug-hope-for-secondaryprogressive-stage-2240 2018-04-02 15:25:49
avatar exit

Unregistered member

09/04/2018 at 14:30

From reading the results shown above, I fail to see that anything has to date been actually achieved to help any one like myself with SPMS and cannot see the relevance of this being written on here as of much use.

Just giving the impression that there is a small breakthrough that is in fact far from true!


MS drug hope for secondary-progressive stage https://www.carenity.co.uk/forum/other-discussions/my-library-multiple-sclerosis/ms-drug-hope-for-secondaryprogressive-stage-2240 2018-04-09 14:30:45

avatar Jennie

Jennie

14/05/2018 at 16:46

avatar Jennie

Jennie

Last activity on 29/08/2019 at 12:27

Joined in 2014


4 comments posted | 2 in the Research and useful tips - Multiple Sclerosis group


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@Walshya  I am in the same situation and just wish to be able to have a couple of ' symptom free ' days - just a couple

 


MS drug hope for secondary-progressive stage https://www.carenity.co.uk/forum/other-discussions/my-library-multiple-sclerosis/ms-drug-hope-for-secondaryprogressive-stage-2240 2018-05-14 16:46:01

avatar Jennie

Jennie

14/05/2018 at 16:48

avatar Jennie

Jennie

Last activity on 29/08/2019 at 12:27

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4 comments posted | 2 in the Research and useful tips - Multiple Sclerosis group


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@Linz1978  Hi - showing my ignorance - what is CBD oil, please ??

 


MS drug hope for secondary-progressive stage https://www.carenity.co.uk/forum/other-discussions/my-library-multiple-sclerosis/ms-drug-hope-for-secondaryprogressive-stage-2240 2018-05-14 16:48:34

avatar stutaylor

stutaylor

23/10/2018 at 17:57

avatar stutaylor

stutaylor

Last activity on 03/11/2020 at 21:02

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9 comments posted | 6 in the Research and useful tips - Multiple Sclerosis group


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Hi Jennie 

Cannabidiol (more commonly known as CBD) has experienced a surge in popularity in recent months, in part due to its availability in high-streethealth shops.

Previously viewed as an option only for the seriously ill, CBD oil is gaining traction among wellness fans, with its promise of being able to provide relief from everything from pain to depression and anxiety

Cannabidiol is derived from the cannabis plant. CBD is not psychoactive, meaning that it won’t make you ‘high’ – the sensation most commonly associated with cannabis. It is, however, reported to offer a range of health and medicinal benefits

hope this helps Google copy and paste!


MS drug hope for secondary-progressive stage https://www.carenity.co.uk/forum/other-discussions/my-library-multiple-sclerosis/ms-drug-hope-for-secondaryprogressive-stage-2240 2018-10-23 17:57:39

avatar JosephineO

JosephineO

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12/11/2018 at 15:53

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avatar JosephineO

JosephineO

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Last activity on 15/07/2024 at 09:21

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989 comments posted | 44 in the Research and useful tips - Multiple Sclerosis group

6 of their responses were helpful to members


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@Jennie @stutaylor‍ 

Hi Jennie, if you follow this link then it will take you to an article that we recently published that explains all about CBD oil, I think oyu will find it helpful :)

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Josephine, Community Manager


MS drug hope for secondary-progressive stage https://www.carenity.co.uk/forum/other-discussions/my-library-multiple-sclerosis/ms-drug-hope-for-secondaryprogressive-stage-2240 2018-11-12 15:53:49

avatar stutaylor

stutaylor

13/11/2018 at 21:27

avatar stutaylor

stutaylor

Last activity on 03/11/2020 at 21:02

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9 comments posted | 6 in the Research and useful tips - Multiple Sclerosis group


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Hi Josephine the link is very good with lots more detail than what I posted. Cheers Stu


MS drug hope for secondary-progressive stage https://www.carenity.co.uk/forum/other-discussions/my-library-multiple-sclerosis/ms-drug-hope-for-secondaryprogressive-stage-2240 2018-11-13 21:27:55
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